Functional Properties of Striatal Fast-Spiking Interneurons
نویسندگان
چکیده
منابع مشابه
Functional Properties of Striatal Fast-Spiking Interneurons
Striatal fast-spiking interneurons (FSIs) have a major influence over behavioral output, and a deficit in these cells has been observed in dystonia and Tourette syndrome. FSIs receive cortical input, are coupled together by gap junctions, and make perisomatic GABAergic synapses onto many nearby projection neurons. Despite being critical components of striatal microcircuits, until recently littl...
متن کاملTarget selectivity of feedforward inhibition by striatal fast-spiking interneurons.
The striatal microcircuitry consists of a vast majority of projection neurons, the medium spiny neurons (MSNs), and a small yet diverse population of interneurons. To understand how activity is orchestrated within the striatum, it is essential to unravel the functional connectivity between the different neuronal types. Fast-spiking (FS) interneurons provide feedforward inhibition to both direct...
متن کاملSelective Activation of Striatal Fast-Spiking Interneurons during Choice Execution
Basal ganglia circuits are essential for the organization and execution of voluntary actions. Within the striatum, fast-spiking interneurons (FSIs) are thought to tightly regulate the activity of medium-spiny projection neurons (MSNs) through feed-forward inhibition, yet few studies have investigated the functional contributions of FSIs in behaving animals. We recorded presumed MSNs and FSIs to...
متن کاملSelective inhibition of striatal fast-spiking interneurons causes dyskinesias.
Fast-spiking interneurons (FSIs) can exert powerful control over striatal output, and deficits in this cell population have been observed in human patients with Tourette syndrome and rodent models of dystonia. However, a direct experimental test of striatal FSI involvement in motor control has never been performed. We applied a novel pharmacological approach to examine the behavioral consequenc...
متن کاملStriatal Fast-Spiking Interneurons: From Firing Patterns to Postsynaptic Impact
In the striatal microcircuit, fast-spiking (FS) interneurons have an important role in mediating inhibition onto neighboring medium spiny (MS) projection neurons. In this study, we combined computational modeling with in vitro and in vivo electrophysiological measurements to investigate FS cells in terms of their discharge properties and their synaptic efficacies onto MS neurons. In vivo firing...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2011
ISSN: 1662-5137
DOI: 10.3389/fnsys.2011.00045